Kuby Immunology 7th Edition By Judith A. Owen – Test Bank

Kuby Immunology 7th Edition By Judith A. Owen – Test Bank

Chapter 8 The Major Histocompatibility Complex and
Antigen Presentation

1. MHC molecules:

A. are secreted by T cells and bind and neutralize antigen in the serum.
B. are membrane-bound molecules found exclusively on T cells.
C. bind repeating patterns found on pathogens.
D. are recognized by T cells.
E. are conserved between individuals.

Answer: D
Section: The Structure and Function of MHC Molecules
Difficulty: 1
Hint: MHC molecules present foreign peptides.

2. Match the following structural characteristics with either MHC class I (I), class II (II), or both (I & II).

a. Contains 2-microglobulin ________
Answer: I
b. Contains two transmembrane domains ________
Answer: II
c. Binds 8-10 amino acid peptides ________
Answer: I
d. Contains two heavy chains ________
Answer: II
e. Has closed ends on the peptide binding groove ________
Answer: I

Section: The Structure and Function of MHC Molecules
Difficulty: 1
Hint: Review Fig. 8-1.

3. A mutation in which part of a viral protein might allow the virus to evade the adaptive immune response because it MHC binding?

A. A TCR contact residue
B. A residue in the transmembrane domain of an envelope protein
C. A residue in the DNA-binding domain
D. An anchor residue
E. An amino acid on the surface of the virus

Answer: D
Section: The Structure and Function of MHC Molecules
Difficulty: 1

Hint: Peptides bind to MHC by inserting side chains into pockets in the peptide-binding groove.

4. MHC polymorphisms tend to cluster:

A. in the peptide-binding groove.
B. in the transmembrane domain.
C. in the coreceptor contact residues.
D. in the framework region.
E. All of the above

Answer: A
Section: The Structure and Function of MHC Molecules
Difficulty: 1
Hint: MHC molecules present foreign peptides.

5. How many different MHC classical class I proteins does each nucleated cell in a human heterozygous at the MHC locus express?

A. None. Only APC express class I.
B. One
C. Two
D. Three
E. Six

Answer: E
Section: General Organization and Inheritance of the MHC
Difficulty: 1
Hint: MHC class I is codominantly expressed.